Using HTML5 and CSS3 for a website will improve its usability, interactivity and appearance. Developing in both HTML5 and CSS3 will also position your website for growth as the web advances. Instead of going back and making changes to your site, you will simply be able to build upon what you already have in place as new standards emerge.
Responsive web design is also a great option for web development. The mobile web is growing by leaps and bounds. If you anticipate a high volume of mobile web users to visit your site, then you will definitely want a responsive design. Responsive design allows the website to seamlessly adapt to any size screen so your site will look great on a mobile device, laptop and desktop. You don’t have to sacrifice usability with responsive design in order to achieve an attractive design on a mobile device.
In fact, even if you don’t currently see a great deal of web traffic from mobile devices, you may still want to consider going with a responsive design for your website. It may not be long before users in your niche begin to adopt the mobile web as their preferred browsing environment. Remember, more and more people are buying smartphones and tablets and will therefore be using their mobile browsers to access the web